CHANGES IN TELOMERE LENGTH OF GUMS IN INDIVIDUALS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
DOI:
https://doi.org/10.35220/2523-420X/2022.1.2Keywords:
telomere length, chronical generalized periodontitis, chronic inflammation, non-alcoholic fatty liver disease.Abstract
Purpose of the study. Determination of telomere length of gingival epitheliocytes in patients with chronic periodontitis against the background of non-alcoholic fatty liver disease and their comparison with spouses. Research methods. Questionnaires, dental examination and PCR scrapings were performed on the surface of the attached gums of patients with non-alcoholic fatty liver disease and their spouses who have the same eating habits. Scientific novelty. It is of scientific interest to study the change the length of the telomere, as a factor in the physiological aging of cells, can also be a marker of the adverse effects of somatic diseases, in particular non-alcoholic fatty liver disease. Conclusions. Periodontal diseases in patients with non-alcoholic fatty liver disease and their spouses had an inflammatory character of various clinical and morphological forms and were represented mainly by chronic generalized periodontitis. Telomere length was significantly shorter in patients with non-alcoholic fatty liver disease compared with somatically healthy respondents. There was a negative relationship between telomere length and chronic generalized periodontitis, as well as the level of hygiene, and the presence of nonalcoholic fatty liver disease. Chronic inflammation and oxidative stress in periodontal tissues in non-alcoholic fatty liver disease contribute to premature cell aging and reduce the telomere length of gum epithelial cells.
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