THE USE OF THE EORTC QLQ – H&N35 IN THE ASSESSMENT OF THE QUALITY OF LIFE OF PATIENTS WITH TUMORS OF THE ORAL CAVITY AND OROPHARYNX DURING INPATIENT TREATMENT
DOI:
https://doi.org/10.35220/2523-420X/2022.2.5Keywords:
oral cavity cancer, long-term conductive postoperative analgesia, pain, quality of life.Abstract
The work is devoted to the assessment of the quality of life of patients with tumors of the oral cavity and oropharynx during inpatient treatment using the EORTC QLQ – H&N3 questionnaire. The purpose of the study was to conduct a comparative assessment of the effectiveness of pain-relieving therapy options with the use of longterm conductive postoperative analgesia and with the use of non-narcotic analgesics in patients with tumors of the oral cavity and oropharynx at the stage of inpatient treatment, based on quality of life indicators. The quality of life was assessed in 38 patients who were divided into two groups depending on postoperative analgesia using the EORTC QLQ questionnaire – H&N35, ECOG and the Karnavskyi index. Statistical processing of the obtained data was carried out using Excel software from the Microsoft Office 2003 package, STATISTICA 5.5 (belongs to the M.I. Pirogov Central Scientific Research Institute of VNMU, license number AXXR910A374605FA) according to the Student’s criterion at p<0.05. Scientific novelty. The obtained results show that, in comparison with the traditional use of non-narcotic analgesics, pain-relieving therapy with the use of TPPZ allows more adequate relief of pain syndrome in patients with tumors of the oral cavity and oropharynx, avoiding the occurrence of pronounced side effects and achieving higher quality of life indicators of patients, which indicates its advantage (p<0.05). Conclusions. Controlled postoperative analgesia with the use of long-term postoperative conductive analgesia has a positive effect on the quality of life. The most informative among the three quality of life indicators used is the integral indicator according to the EORTC-QLQH&N35 questionnaire. The use of quality of life indicators and their research at the stage of inpatient treatment allows, if necessary, to make justified corrections in the process of treatment and rehabilitation measures to improve the quality of life of patients with tumors of the oral cavity and oropharynx.
References
Рак в Україні, 2017–2018. Захворюваність, смертність, показники діяльності онкологічної служби. Бюлетень національного канцер-реєстру України. 2019. № 20. URL: http://ncru.inf.ua/publications/BULL_20/ PDF_E/16-17%20prot.pdf
Almståhl A, Alstad T, Fagerberg-Mohlin B, Carlén A, Finizia C. Explorative study on quality of life in relation to salivary secretion rate in patients with head and neck cancer treated with radiotherapy. Head Neck. 2016;38(5):782–791. https://doi.org/10.1002/hed.23964
Barrios R, Bravo M, Gil-Montoya JA, Martínez- Lara I, García-Medina B, Tsakos G. Oral and general health-related quality of life in patients treated for oral cancer compared to control group. Health Qual Life Outcomes. 2015;13:9. https://doi.org/10.1186/s12955-014-0201-5
Davudov MM, Harirchi I, Arabkheradmand A, et al. Evaluation of quality of life in patients with oral cancer after mandibular resection: Comparing no reconstruction, reconstruction with plate, and reconstruction with flap. Medicine. 2019;98(41):e17431. https://doi.org/10.1097/ MD.0000000000017431
De Cicco D, Tartaro G, Ciardiello F, et al. Health-Related Quality of Life in Oral Cancer Patients: Scoping Review and Critical Appraisal of Investigated Determinants. Cancers. 2021;13(17):4398. Published 2021 Aug 31. https://doi.org/10.3390/cancers13174398
Jitender, S., Mahajan, R., Rathore, V., Choudhary, R. (2018). Quality of life of cancer patients. Journal of experimental therapeutics & oncology. 2018;12(3): 217–221.
Lal P, Nautiyal V, Verma M, Yadav R, Maria Das KJ, Kumar S. Objective and subjective assessment of xerostomia in patients of locally advanced head-and-neck cancers treated by intensity-modulated radiotherapy. Journal of cancer research and therapeutics. 2018;14(6):1196– 1201. https://doi.org/10.4103/jcrt.JCRT_200_17
Lydiatt WM, Patel SG, O’Sullivan B, et al. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):122–137. https://doi.org/10.3322/caac.21389
Макаров А.В., Шпак В.С., Сокур І.В., Савиць- кий І.В. Використання в оцінці якості життя онкологічних хворих в ході стаціонарного лікування після мастектомії. Експериментальна і клінічна медицина. 2014;62(1):155–159.
Мухаровська І.Р. Якість життя онкологічних хворих на етапах лікувального процесу. Психіатрія, неврологія та медична психологія. 2017;1 (7): 91–95.
Nemeth D, Zaleczna L, Huremovic A, Engelmann J. Importance of chewing, saliva, and swallowing function in patients with advanced oral cancer undergoing preoperative chemoradiotherapy: a prospective study of quality of life. Int J Oral Maxillofac Surg. 2017;46(10): 1229–1236. https://doi.org/10.1016/j.ijom.2017.05.005
Oliveira K. G., Zeidler S. V., Podestá J. R., Sena A., Souza E. D., Lenzi J., Bissoli N. S., Gouvea, S. A. Influence of pain severity on the quality of life in patients with head and neck cancer before antineoplastic therapy. BMC cancer. 2014;14: 39. https://doi.org/10.1186/1471-2407-14-39
Ошивалова О. О., Зюков О. Л., Калюжна Л. Д. Оцінка якості життя хворих з передонкологічною та онкологічною патологією шкіри. Вісник проблем біології і медицини. 2017;2: 328–332.
Singer S, Arraras JI, Chie WC, et al. Performance of the EORTC questionnaire for the assessment of quality of life in head and neck cancer patients EORTC QLQ-H&N35: a methodological review. Qual Life Res. 2013;22(8):1927-1941. https://doi.org/10.1007/s11136- 012-0325-1
Valdez JA, Brennan MT. Impact of Oral Cancer on Quality of Life. Dent Clin North Am. 2018;62(1):143-154. https://doi.org/10.1016/j.cden.2017.09.001
Wiegand S, Wichmann G, Dietz A. Perspectives of Induction With Chemo and/or Immune Check Point Inhibition in Head and Neck Organ Preservation Treatment. Front Oncol. 2019;9:191. https://doi.org/10.3389/ fonc.2019.00191
Yuwanati M, Gondivkar S, Sarode SC, et al. Oral health-related quality of life in oral cancer patients: systematic review and meta-analysis. Future Oncol. 2021; 17(8):979-990. https://doi.org/10.2217/fon-2020-0881
