THE INFLUENCE OF EXPERIMENTAL DEMENTIA ON BEHAVIORAL REACTIONS AND INDICATORS OF JAW ATROPHY IN RATS

Abstract

Purpose of the study. Evaluation of the effect of aluminum intoxication on the cognitive properties of rats and indicators of atrophic processes in periodontal tissues of experimental animals. Materials and methods of research. Experimental studies were conducted in accordance with the requirements of the law of Ukraine “on the protection of animals from ill-treatment” and the procedure for conducting experiments and experiments on animals by scientific institutions in compliance with bioethical standards. The experiment was conducted on 16 male white rats, which were divided into 2 groups: Group 1 – intact animals (n = 8); Group 2 – administration of an aqueous solution of AlCl3 (dementia simulation) (n = 8). Rats were kept in a standard vivarium under constant temperature and humidity. Research results and their discussion. The average weight of rats in the groups was 258.5 G at the beginning of the experiment and increased at the end of the experiment. The features of behavioral responses of rats of all groups in the Barnes maze using extraneous stimuli were studied. The degree of resorptive processes in rat periodontal tissues was studied. The effect of aluminum intoxication on the indicators of alveolar process atrophy in experimental rats was also studied. Conclusions. It was shown that prolonged intoxication with aluminum chloride in rats led to an increase in the number of errors by 1.5 times, the time of passage of the maze by 2.2 times compared to the control. During the study period, a change in the search strategy for the “rescue” well was observed from “sequential” to “random”, which confirms the reproduction of experimental dementia in rats. A significant increase in the degree of atrophy of the alveolar process of the jaws of rats by 17.1 % in conditions of intoxication of experimental rats with aluminum chloride was established, which justifies the need to use therapeutic and preventive agents of periodontal protective action.