PERIODONTAL-PROTECTIVE PROPERTIES OF ORAL GEL “VIOLET” IN EXPERIMENTAL CALCIUM-DEFICIENCY STATE
DOI:
https://doi.org/10.35220/2523-420X/2023.2.2Keywords:
mineral metabolism, energy metabolism, nitrogen metabolism, experiment, periodontitis, oral gel.Abstract
Purpose of the study. Experimental study of the periodontal protective properties of Violet oral gel on a toxic calcium-deficient model. Materials and methods of research. Experimental modeling of periodontal pathology in Experimental Animals against the background of a toxic calcium-deficient state was carried out for 30 days according to the following scheme: – 4 groups were formed: 1 group – intact animals; Group 2 – animals were given EDTA solution (2 %) daily with drinking water and three times a week were administered per os drug “Warfarin Orion” at a dose of 5 mg/kg (in terms of active ingredient warfarin sodium – 0.01 mg/kg) Group 3 – administration of the drug “Warfarin Orion” and 2 % solution of EDTA (2 %) and application of gel “Placebo” to the membrane of the alveolar process; group 4 – administration of the drug “Warfarin Orion” and 2 % solution of EDTA and starting from 7 days daily, within 3 weeks, application of gel “Violet” to the mucous membrane of the alveolar process, after which the activity of alkaline phosphatase, lactate dehydrogenase, succinate dehydrogenase, cytochrome oxidase and calcium and phosphorus content were studied in the blood and periodontal tissues. Conclusions. 1. Against the background of the development of calcium deficiency states and pathology of bone tissue, hypoxic states develop both at the systemic level and locally, in periodontal tissues, due to a drop in the level of tissue oxygenation, the development of endothelial dysfunction, blocking redox processes in periodontal tissues and activation of glycolysis processes. 2. The study of periodontal-protective properties of the gel for the oral cavity “Violet” against the background of the occurrence of calcium deficiency states showed the effectiveness of its use in terms of the activity of redox processes (the most positive changes in the indicator of LDH/SDG+CHO, which characterizes the ratio of anaerobic / aerobic processes in 3.3 times.
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