THE EFFECT OF THE DEVELOPED THERAPEUTIC AND PREVENTIVE COMPLEXES ON THE CONDITION OF THE HARD TISSUES OF THE TEETH, ATROPHY OF THE ALVEOLAR PROCESS AND BODY WEIGHT OF RATS WITH TEETHING DISORDER AGAINST THE BACKGROUND OF A CARIOGENIC DIET
DOI:
https://doi.org/10.35220/2523-420X/2024.1.3Keywords:
caries, caries diet, alveolar process atrophy, ratsAbstract
Introduction. The high intensity of caries of the permanent teeth among patients with delayed teething indicates the need to develop modern methods of prevention and treatment of major dental diseases in such patients. Objective: to study the effect of the developed therapeutic-preventive complexes (TPC) on weight gain, the number and depth of carious cavities, atrophy of the alveolar process in rats with teething disorder against the background of a cariogenic diet. Materials and methods. The 1st (control) group consisted of 8 intact rats. The 2nd group consisted of 10 rats with early teething (born to females receiving L-thyroxine during pregnancy and lactation). The 3rd group comprised 10 rats with early teething (born to females receiving L-thyroxine during pregnancy and lactation) who received a medical preventive complex (MPC) No1. The 4th group consisted of 10 rats with a delayed teething (born to females receiving antibiotics during pregnancy and lactation). The 5th group included 11 rats with delayed teething (born to females receiving antibiotics during pregnancy and lactation) who received MPC No2. The 6th group covered rats, which were modeled the delay in teething (born to females who received Mercazolil during pregnancy and lactation). The 7th group consisted of rats with delayed teething (born to females receiving Mercazolil during pregnancy and lactation) who received MPC No2. Calcite gel was applied to the teeth of rats receiving MPC No. 1 within 20 days. In the future, Biotrit gel was applied to the teeth Denta within 20 days. After that the teeth of rats were treated with the system for deep fluoridation Ftorcalcit-E three times every other day. Orally the rats received Dent’s Biotrite as food. Calcite gel was applied to the teeth of rats receiving MPC No2 in the morning and Biotrit Denta gel in the evening. The rats received Lactiale Germaine Forte, Mineralol and Biotrite Denta orally. The depth of caries damage, the number of carious cavities in the teeth, the average number per 1 rat was evaluated. The degree of atrophy of the alveolar process was determined by the method of Nikolaeva. Results. The use of TPC No. 1 could reduce the number of carious cavities by 2,74 times, and the depth of tooth decay by 2,8 times. The use of TPC No. 2 in rats with delayed teething allowed to reduce the number of carious cavities in the rats of the 5th group by 2,9 times, and the depth of carious cavities by 3.03 times in comparison with rats of the 4th group. In rats of the 7th group, a decrease in the number of carious cavities was established by 2,6 times, and the depth of carious cavities by 3,1 times in comparison with rats of the 6th group. Conclusions. The results of the study of the number and depth of carious cavities, the level of atrophy of the alveolar process of the lower jaw are evidence of high efficiency of the applied TPC No. 1 and TPC No.2.
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