ALLELE POLYMORPHISM OF VITAMIN D RECEPTOR GENE (VDR) IN CHILDREN WITH MULTIPLE CARIES
Keywords:
caries, multiple caries, gene, vitamin D receptorAbstract
Aim of research: to conduct molecular and genetic analysis of allele polymorphism of vitamin D receptor gene and determine possible genetic factors predisposing to multiple caries formation. Materials and methods: Extraction of DNA out of buccal epithelium of 62 adolescents aged 12-15 years (24 males and 38 females, residing in Lviv and Lviv region) has been performed. Among them - 32 individual with caries intensity over 8 (decompensated form) and 30 - with caries intensity below 4 teeth (compensated form). The paper presents an analysis of the alleles and genotypes frequency of polymorphic loci ApaI and TaqI of vitamin D receptor gene (VDR) among children with multiple caries compare to control group (children with less than 4 caries teeth). Results: Differences in the frequencies of VDR TaqI genotypes and alleles in children with multiple caries compared to control are not reached statistically significant values. The allele a of polymorphic locus ApaI of VDR gene increases the risk of multiple caries in 2.15 times.
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