EFFICACY OF THE COMBINATION OF BONE GRAFTING MATERIALS WITH PLATELET-RICH FIBRIN IN AN EXPERIMENTAL MODEL OF MANDIBULAR BONE DEFECTS
DOI:
https://doi.org/10.35220/2523-420X/2025.4.7Keywords:
platelet-rich fibrin, bone regeneration, bone grafting materials, Bauers, PRF, osteoconduction, ABGraftAbstract
The addition of platelet-rich fibrin (PRF) to bone grafting materials is a promising approach to enhance the effectiveness of mandibular bone tissue regeneration. However, comparative data on the synergistic effect of PRF with xenogeneic (Bauers®, Straumann®) and synthetic (ABGraft®, Maxresorb®) materials in the same experimental model are lacking. Objective – to experimentally evaluate the efficacy of combinations of domestic and imported bone grafting materials with PRF compared to the isolated use of materials in a model of mandibular bone defects in rabbits. Materials and Methods. The study was conducted on 32 New Zealand white rabbits, divided into 8 groups of 4 animals each. Groups 1-3 (control): Straumann®, Bauers®, Maxresorb®, ABGraft® without PRF. Groups 4-6 (experimental): analogous materials + PRF. Standardized defects (5 mm in diameter) were created in the region of the mandibular angle. Evaluation on days 30 and 60: radiologically (bone fill, %), histologically (osteocyte density, vascularization), and morphometrically. Statistical analysis: ANOVA, Student’s t-test (p <0.05). Results. On day 60, in groups with PRF, bone fill indicators increased by 18-28% compared to the control (p <0.01). The highest results: Bauers® + PRF (82.7 ± 4.5%) and Straumann® + PRF (85.3 ± 4.1%), the difference was not statistically significant (p = 0.267). Synthetic materials with PRF: Maxresorb® + PRF (68.5 ± 5.2%), ABGraft® + PRF (65.4±4.8%), significantly outperformed control without PRF (p <0.001), but were inferior to xenogeneic materials with PRF (p <0.05). Osteocyte density on day 60: Bauers® + PRF – 71.4±6.2, Straumann® + PRF – 73.8 ± 5.9, Maxresorb® + PRF – 58.3±5.4, ABGraft® + PRF – 55.7±5.1 cells/field (p<0.05). Conclusions. The addition of PRF to bone grafting materials increases regeneration indicators by 18-28% regardless of the material type. The combination of the domestic Bauers® with PRF is clinically equivalent to the imported Straumann® + PRF, justifying import substitution. Synthetic materials with PRF showed moderate efficacy, suitable for small defects
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