CHANGES IN THE ACTIVITY OF THE ANTIOXIDANT SYSTEM IN THE BLOOD OF RATS WITH EXPERIMENTAL PERIODONTITIS UNDER ALTERED REACTIVITY
DOI:
https://doi.org/10.35220/2523-420X/2026.1.1Keywords:
antioxidant system, superoxide dismutase, ceruloplasmin, hypoergic reaction, hyperergic reaction, rats, periodontal tissue, oxidative stressAbstract
Periodontal tissue diseases are among the leading causes of tooth loss and reduced masticatory efficiency. The reactivity of the organism plays a significant role in the progression and treatment of periodontal tissue damage. The aim of this experimental study was to investigate the activity of the antioxidant system in rats with altered reactivity. Materials and methods. Experiments were conducted on 50 white nonlinear rats divided into three groups: group I – rats with hypoergic reaction (n=20), group II – rats with hyperergic reaction (n=20), and a control group with normergic reaction (n=10). Hypoergic and hyperergic reactions were modeled by intramuscular administration of cyclophosphamide and lipopolysaccharide, respectively, for 7 days. Blood samples were collected 1 and 7 days after the start of the experiment. Superoxide dismutase (SOD) activity and ceruloplasmin (CP) levels were measured to evaluate the antioxidant system. Results and Discussion. Results showed that both SOD activity and CP content decreased on day 1 in rats with altered reactivity. By day 7, further decrease in SOD was observed in the hypoergic group, whereas CP levels increased slightly in the hyperergic group. Conclusions. These findings indicate that changes in systemic reactivity significantly affect the antioxidant defense mechanisms, which may have implications for the pathogenesis and treatment of periodontal diseases.
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