THE PATHOGENETIC ROLE OF THE BACTERIA HELICOBACTER PYLORI IN THE DEVELOPMENT OF INFLAMMATORY DISEASES OF THE ORAL CAVITY
DOI:
https://doi.org/10.35220/2523-420X/2022.1.1Keywords:
Helicobacter pylori, periodontitis, periodontal diseases, oral dysbiosis, periodontal treatment.Abstract
Helicobacter pylori infection is one of the most common chronic human infections. The etiological role of the bacterium Helicobacter pylori in the development of such diseases as chronic gastritis, peptic ulcer disease of the stomach and duodenum, MALT lymphoma, and stomach cancer has been proven. Previously, it was believed that the only natural habitat of the bacterium is the mucous membrane of the stomach, but numerous studies have shown that the bacterium H.pylori is also found in various biotopes of the oral cavity (dental plaque, saliva, periodontal pockets, surfaces of dental prostheses), supporting and strengthening various diseases of the oral cavity. The aim of the work was to evaluate the relationship between inflammatory diseases of the oral cavity and helicobacter invasion of the body, as well as to propose a possible mechanism of the development of inflammatory changes in the oral cavity against the background of helicobacteriosis. Materials and methods. We examined 43 patients with Helicobacter pyloriassociated gastrointestinal pathology and 42 patients of the same age without somatic pathology, including without gastrointestinal pathology associated with Helicobacter pylori. Clinical and laboratory research methods (clinical, instrumental, biochemical, histological methods) were used. Results. Comparing the data of clinical observations and the results of laboratory studies of patients with inflammatory periodontal disease on the background of Helicobacter pylori-associated gastrointestinal pathology, obtained in different observation periods, we can assume that basic dental treatment of periodontal disease in such patients undergoing eradication therapy does not provide stable anti-inflammatory, antimicrobial and antioxidant effect, which leads to reduced periods of remission and recurrence of periodontal disease, where oral dysbiosis plays a crucial role. Conclusions. To normalize the condition of the oral cavity, eliminate inflammatory changes and dysbiosis, patients with gastrointestinal diseases associated with Helicobacter pylori, together with basic therapy of periodontal disease and treatment of the main somatic disease, it is advisable to prescribe correct differentiated schemes for prevention and treatment of oral pathology. recurrence of the disease.
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