THE ROLE OF VITAMIN D DEFICIENCY IN THE DEVELOPMENT OF DENTAL CARIES IN CHILDREN

Authors

  • A.V. Pachevska National Pirogov Memorial Medical University
  • O.I. Popova National Pirogov Memorial Medical University
  • D.M. Kasianenko National Pirogov Memorial Medical University
  • I.Y. Drachevska National Pirogov Memorial Medical University
  • M.V. Popov National Pirogov Memorial Medical University
  • I.V. Simonova National Pirogov Memorial Medical University

DOI:

https://doi.org/10.35220/2523-420X/2024.1.17

Keywords:

vitamin D deficiency, dental caries, children

Abstract

The aim of this study is to provide a narrative review of proposed etiopathogenetic mechanisms by which vitamin D deficiency causes dental caries in children. Materials and methods. Over the past decade Polishand English-language publications addressing the issue of vitamin D deficiency and caries development in children have been analyzed. Scientific novelty. While dental caries has long been known that is a multifactorial disease and one of the most common health issues in childhood, a recent meta-analysis involving children from five continents revealed a global prevalence of 46.2% for deciduous teeth caries and 53.8% for permanent teeth. Traditionally, tooth decay has been considered as an infectious disease caused by poor oral hygiene and the aggressive action of the microbial biofilm of the oral cavity. Dentists of many countries are trying to answer the question of what causes caries in a child. Whereas biological effects of vitamin D were previously almost exclusively associated with bone metabolism (calcium deficiency causing rickets in infants and osteomalacia in adults), today most researchers consider vitamin D deficiency as a triggering factor in the etiopathogenesis of dental caries in children. Current research has established that impaired mineralisation of teeth during development, deterioration of enamel quality, and increased susceptibility to caries development may be entailed by vitamin D deficiency. Researchers determine that vitamin D deficiency in children in future leads not only to the progression of dental caries, but also to jaw structure disorders, malocclusion, teeth defects and early tooth loss. Conclusions. Dental caries is one of the most common health problems in childhood. Numerous studies have shown that vitamin D deficiency is associated with caries of deciduous and permanent teeth in children. The association between vitamin D deficiency and dental caries is clear enough to consider vitamin D deficiency as a risk factor for dental caries in children, and dental caries itself as a symptom of vitamin D deficiency.

References

Kazeminia M., Abdi A., Shohaimi S., Jalali R., Vaisi-Raygani A., Salari N., Dental caries in primary and permanent teeth in children’s worldwide, 1995 to 2019: a systematic review and meta-analysis. Head & face medicine. 2020. № 1(16). Р.22. https://doi.org/10.1186/s13005-020-00237-z

Selwitz R.H., Ismail A.I., Pitts N.B., Dental caries. Lancet (London, England). 2007. № 369(9555). Р. 51–59. https://doi.org/10.1016/S0140-6736(07)60031-2

Pitts N. B., Zero D. T., Marsh P. D., Ekstrand K., Weintraub J. A., Ramos-Gomez F. et al. Dental caries. Nature reviews. Disease primers. 2017. № 3. Р. 17030. https://doi.org/10.1038/nrdp.2017.30

Tinanoff N., Baez R. J., Diaz Guillory C., Donly K. J., Feldens C. A., McGrath C. et al. Early childhood caries epidemiology, aetiology, risk assessment, societal burden, management, education, and policy: Global perspective. International journal of paediatric dentistry. 2019. № 3(29). Р. 238–248. https://doi.org/10.1111/ipd.12484

Kirthiga M., Murugan M., Saikia A., Kirubakaran R., Risk Factors for Early Childhood Caries: A Systematic Review and Meta-Analysis of Case Control and Cohort Studies. Pediatric dentistry. 2019. № 21(41). Р.95–112.

Thang Le V. N., Kim J. G., Yang Y. M., Lee D. W., Risk Factors for Early Childhood Caries: An Umbrella Review. Pediatric dentistry. 2021. № 3(43). Р.176–194.

Moynihan P. J., Kelly S. A., Effect on caries of restricting sugars intake: systematic review to inform WHO guidelines. Journal of dental research. 2014. № 1(93). Р.8–18. https://doi.org/10.1177/0022034513508954

Sheiham A., James W. P., A reappraisal of the quantitative relationship between sugar intake and dental caries: the need for new criteria for developing goals for sugar intake. BMC public health. 2014. № 14 Р. 863. https://doi.org/10.1186/1471-2458-14-863

Mellanby M., Pattison C. L.,THE ACTION OF VITAMIN D IN PREVENTING THE SPREAD AND PROMOTING THE ARREST OF CARIES IN CHILDREN. British medical journal. 1928. № 2(3545). Р.1079–1082. https://doi.org/10.1136/bmj.2.3545.1079

Hossein-nezhad A., Holick M. F., Vitamin D for health: a global perspective. Mayo Clinic proceedings. 2013. № 7(88). Р. 720–755. https://doi.org/10.1016/j.mayocp.2013.05.011

Palermo N. E., Holick M. F., Vitamin D, bone health, and other health benefits in pediatric patients. Journal of pediatric rehabilitation medicine. 2014. № 2(7). Р.179–192. https://doi.org/10.3233/PRM-140287

Krawiec M., Dominiak M., The role of vitamin D in the human body with a special emphasis on dental issues: Literature review. Dental and medical problems. 2018. № 4(55). Р. 419–424. https://doi.org/10.17219/dmp/99051

Botelho J., Machado V., Proença L., Delgado A. S., Mendes, J. J., Vitamin D Deficiency and Oral Health: A Comprehensive Review. Nutrients. 2020. № 5(12). Р. 1471. https://doi.org/10.3390/nu12051471

Hujoel P. P.,Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis. Nutrition reviews. 2013. № 21(71). Р. 88–97. https://doi.org/10.1111/j.1753-4887.2012.00544.x

Schroth R. J., Levi J. A., Sellers E. A., Friel J., KliewerE., Moffatt M. E., Vitamin D status of children with severe early childhood caries: a case-control study. BMC pediatrics. 2013. № 13. Р.174. https://doi.org/10.1186/1471-2431-13-174

Schroth R. J., Rabbani R., Loewen G., Moffatt M. E., Vitamin D and Dental Caries in Children. Journal of dental research. 2016. № 2(95). Р. 173–179. https://doi.org/10.1177/0022034515616335

Herzog K., Scott J. M., Hujoel P., SeminarioA. L., Association of vitamin D and dental caries in children: Findings from the National Health and Nutrition Examination Survey, 2005-2006. Journal of the American Dental Association (1939). 2016. № 1(147). Р.413–420. https://doi.org/10.1016/j.adaj.2015.12.013

Gyll J., Ridell K., Öhlund I., Karlsland Åkeson P., Johansson I., Lif Holgerson P., Vitamin D status and dental caries in healthy Swedish children. Nutrition journal. 2018. № 1(17). Р. 11. https://doi.org/10.1186/s12937-018-0318-1

Theodoratou E., Tzoulaki I., Zgaga L., Ioannidis J. P., Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. 2014. BMJ (Clinical research ed.).348 Р.g2035. https://doi.org/10.1136/bmj.g2035

Kim I. J., Lee H. S., Ju H. J., Na J. Y., Oh H. W., A cross-sectional study on the association between vitamin D levels and caries in the permanent dentition of Korean children. BMC oral health. 2018. № 1(18). Р. 43. https://doi.org/10.1186/s12903-018-0505-7

Almoudi M. M., Hussein A. S., Abu Hassan, M. I., Schroth R. J. Dental caries and vitamin D status in children in Asia. Pediatrics international : official journal of the Japan Pediatric Society. 2019. № 4(61). Р. 327–338. https://doi.org/10.1111/ped.13801

Williams T. L., Boyle J., Mittermuller B. A., Carrico C., Schroth R. J., Association between Vitamin D and Dental Caries in a Sample of Canadian and American Preschool-Aged Children. Nutrients. 2021. № 12(13). Р.44-65. https://doi.org/10.3390/nu13124465

Carvalho Silva C., Gavinha S., Manso M. C., Rodrigues R., Martins S., Guimarães J. T.,. Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area. Nutrients. 2021. № 1(13),. Р.166. https://doi.org/10.3390/nu13010166

Jha A., Jha S., Shree R., Kumar A., Menka K., Shrikaar M., Association between Serum Ferritin, Hemoglobin, Vitamin D3, Serum Albumin, Calcium, Thyrotropin-releasing Hormone with Early Childhood Caries: A Case-Control Study. International journal of clinical pediatric dentistry. 2021. № 5(14). Р. 648–651. https://doi.org/10.5005/jp-journals-10005-2028

Xavier T. A., Madalena I. R., da Silva R. A. B., da Silva L. A. B., Silva M. J. B., De RossiA. et al. Vitamin D deficiency is a risk factor for delayed tooth eruption associated with persistent primary tooth. Acta odontologica Scandinavica. 2021. № 8(79). Р. 600–605. https://doi.org/10.1080/00016357.2021.1918762

Chen Z., Lv X., Hu W., Qian X., Wu T., Zhu Y., Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou. Frontiers in public health. 2021. № 9. Р. 675403. https://doi.org/10.3389/fpubh.2021.675403

Pu R., Fu M., Li N., Jiang Z., A certain protective effect of vitamin D against dental caries in US children and youth: A cross-sectional study. Journal of public health dentistry. 2023. № 3(83),. Р. 231–238. https://doi.org/10.1111/jphd.12571

Rusińska A., Płudowski P., Walczak M., Borszewska-Kornacka M. K., Bossowski A., Chlebna-Sokół D. et al. Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies-2018 Update. 2018. Frontiers in endocrinology. № 9. Р. 246. https://doi.org/10.3389/fendo.2018.00246

Sobiech P., Olczak-Kowalczyk D., Hosey M. T., Gozdowski D., Turska-Szybka A., Vitamin D Supplementation, Characteristics of Mastication, and Parent-Supervised Toothbrushing as Crucial Factors in the Prevention of Caries in 12- to 36-Month-Old Children. 2022). Nutrients. № 14(20). Р. 43-58. https://doi.org/10.3390/nu14204358

Carvalho Silva C., Mendes R., Manso M. D. C., Gavinha S., Melo P., Prenatal or Childhood Serum Levels of Vitamin D and Dental Caries in Paediatric Patients: A Systematic Review. Oral health & preventive dentistry. 2020. № 1(18). Р. 653–667. https://doi.org/10.3290/j.ohpd. a45089

van der Tas J. T., Elfrink M. E. C., Heijboer A. C., Rivadeneira F., Jaddoe V. W. V., Tiemeier H. et al. Foetal, neonatal and child vitamin D status and enamel hypomineralization. Community dentistry and oral epidemiology. 2018. № 4(46). Р. 343–351. https://doi.org/10.1111/cdoe.12372

Silva M. J., Riggs E., Kilpatrick N. M., Getting ahead of the oral health game: it starts before we’re born? Australian dental journal. 2019. V.64. Suppl 1, Р.4–9. https://doi.org/10.1111/adj.12672

Schroth R. J., Christensen J., Morris M., Gregory P., Mittermuller B. A., Rockman-Greenberg C., The Influence of Prenatal Vitamin D Supplementation on Dental Caries in Infants. Journal (Canadian Dental Association). 2020. V86. k13.

Tanaka K., Hitsumoto S., Miyake Y., Okubo H., Sasaki S., Miyatake N., Higher vitamin D intake during pregnancy is associated with reduced risk of dental caries in young Japanese children. Annals of epidemiology. 2015. № 8(25). Р. 620–625. https://doi.org/10.1016/j.annepidem.2015.03.020

Machado V., Lobo S., Proença L., Mendes J. J., Botelho J., Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis. Nutrients. 2020. № 8(12). Р. 2177. https://doi.org/10.3390/nu12082177

Carvalho Silva C., Mendes R., Manso M. D. C., Gavinha S., Melo P., Prenatal or Childhood Serum Levels of Vitamin D and Dental Caries in Paediatric Patients: A Systematic Review. Oral health & preventive dentistry. 2020. № 1(18). Р. 653–667. https://doi.org/10.3290/j.ohpd.a45089

Caufield P. W., Li Y., Bromage T. G., Hypoplasia-associated severe early childhood caries--a proposed definition. Journal of dental research. 2012. № 6(91). Р. 544–550. https://doi.org/10.1177/0022034512444929

Hussein A. S., Almoudi M. M., Abu-Hassan M. I., Schroth R. J., Saripudin B., Mohamad, M. S. F., Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children. 2021. The Journal of clinical pediatric dentistry. № 6(45). Р. 414–420. https://doi.org/10.17796/1053-4625-45.6.8

Sari D. K., Sari L. M., Laksmi L. I., Farhat, The Moderate Correlation Between 25(OH)D Serum and Saliva in Healthy People with Low Vitamin D Intake. International journal of general medicine. 2021. V.14. Р. 841–850. https://doi.org/10.2147/IJGM.S302912

Mumford S. L., Garbose R. A., Kim K., Kissell K., Kuhr D. L., Omosigho et al. Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. The lancet. Diabetes & endocrinology. 2018. № 6(9). Р. 725–732. https://doi.org/10.1016/S2213-8587(18)30153-0

Reed S. G., Voronca D., Wingate J. S., Murali M., Lawson A. B., Hulsey T. C., Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: a pilot study. Pediatric dental journal : international journal of Japanese Society of Pediatric Dentistry. 2017. № 1(27). Р. 21–28. https://doi.org/10.1016/j.pdj.2016.08.001

Youssef D. A., Miller C. W., El-Abbassi A. M., Cutchins D. C., Cutchins C., Grant W. B. et al. Antimicrobial implications of vitamin D. Dermato-endocrinology. 2011. № 3(4). Р. 220–229. https://doi.org/10.4161/derm.3.4.15027

Golden N. H., Abrams S. A., Committee on Nutrition. Optimizing bone health in children and adolescents. 2014. Pediatrics. № 4(134). Р. 1229–1243. https://doi.org/10.1542/peds.2014-2173

Holick M. F., The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Reviews in endocrine & metabolic disorders. 2017. № 2(18). Р.153–165. https://doi.org/10.1007/s11154-017-9424-1

Heaney R. P., Vitamin D in health and disease. Clinical journal of the American Society of Nephrology : CJASN. 2008. № 3(5). Р. 1535–1541. https://doi.org/10.2215/CJN.01160308

Published

2024-06-05

How to Cite

Пачевська, А., Попова, О., Касьяненко, Д., Драчевська, І., Попов, М., & Сімонова, І. (2024). THE ROLE OF VITAMIN D DEFICIENCY IN THE DEVELOPMENT OF DENTAL CARIES IN CHILDREN. Innovation in Stomatology, (1), 116–124. https://doi.org/10.35220/2523-420X/2024.1.17