MMP8 AND OSTEOPONTIN BIOMARKERS IN BREAST CANCER PATIENTS IN THE FRONTLINE ZONE IN DIAGNOSTICS OF DENTAL PATHOLOGY
DOI:
https://doi.org/10.35220/2523-420X/2024.4.8Keywords:
breast cancer, dental complications, biological markers, chemotherapy, combat zoneAbstract
Purpose of the study. Study of the dynamics of the concentration of MMP8, osteopontin, Ca2+ ions, as well as the pH level in patients with breast cancer on the background of chemotherapy and specific dental treatment, who are forcibly treated in facilities in the war zone. Research methods. To detect and confirm dental diseases, clinical and instrumental research methods were used, which included: examination of the oral cavity, probing, palpation and percussion of the teeth, use of caries markers. To detect and confirm dental diseases, clinical and instrumental research methods were used, which included: examination of the oral cavity, probing, palpation and percussion of the teeth, use of caries markers. Using immunoenzymatic analysis using the Immuno-Chem-2100 immunoenzymatic complex, the content of bone tissue destruction markers: matrix metalloproteinase 8 and osteopontin was determined in the oral fluid. Scientific novelty. Studies of biomarker levels are of clinical significance for risk identification, disease detection and progression, and assessment of therapy outcomes. Using various laboratory methods for studying the composition of oral fluid, it is possible to determine the activity of substances involved in metabolism in dental diseases. Conclusions. Thus, the conducted studies have established a statistically significant increase in MMP 8 and, on the contrary, a decrease in osteopontin concentration in patients who are forcibly treated in facilities in the combat zone. The role of both MMP 8 and osteopontin in the pathogenesis of dental diseases in patients with malignant breast tumors has been established. The data we obtained substantiate the feasibility of their use as diagnostic markers, as well as laboratory screening of the effectiveness of dental treatment in patients in this category.
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