PATHOGENETICAL BASIS FOR THE DEVELOPMENT OF GENERALIZED PERIODONTITIS SIMULTANEOUS TO THE DISORDERS IN METABOLISM OF CALCIUM AND VITAMIN D

Abstract

Vitamin D possesses a wide range of biological functions major of which is participation in calcium homeostasis and immunotropic effects wich make studying of its status in patients with generalized periodontitis interesting. In our research insufficiency of vitamin D in patients with generalized periodontitis was found, and also increase of level of the ionized calcium against a disbalance in system hormonal regulation of calcium homeostasis has been revealed: decrease in a calcitonin levels and normal values of PTH. Low osteocalcin values testify to decrease in speed of bone formation. The similar condition of calcium homeostasis can be a consequence of insufficiency of vitamin D that makes the further studying of this question perspective. To reveal the pathogenetic mechanisms of the influence of disorders in metabolism of vitamin D upon the development of generalized periodontitis. The patients with general somatic pathology, able to affect the state of mineral metabolism (pathology of thyroid gland, diabetes mellitus, etc.), were not included into the investigation. During the analysis of the stomatological state of the patients with CCG the statistically important differences in the state of hard tissues and periodontologic indices in comparison to the control group were found.