NAPLES PROGNOSTIC SCORE AS A NEW COMBINED INDEX OF INFLAMMATION AND NUTRITIONAL STATUS BIOMARKERS AT PATIENTS WITH CHRONIC RECURRENT APHOTIC STOMATITIS
DOI:
https://doi.org/10.35220/2523-420X/2025.2.27Keywords:
recurrent aphthous stomatitis inflammatory marker; systemic immune inflammation index; nutritional indicators; Naples Prognostic ScoreAbstract
Purpose of the study. Assessment of the potential of the new prognostic Naples scale by determining the prognostic index of nutrition and systemic inflammation at ill individuals with CRAS with an emphasis on the mechanisms of their modification. Research methods.The study involved 83 patients aged 20-45 years, of whom 61 were patients with CRAS (main group) and 22 healthy individuals (control group). A clinical, laboratory, medical and social research method was conducted. Hematological examination included determination of albumin and total cholesterol concentrations in serum according to standard methods using a digital hematological analyzer Beckman Coulter dxc 700 au (Germany); determination of leukogram parameters – on an Erba Elite 580 analyzer (Sweden). Calculation of hematological marker values – NLR was determined as the number of neutrophils/lymphocytes, LMR – as the number of lymphocytes/number of monocytes. The final calculation of NPS was performed using dichotomous values of NLR, LMR albumin and total cholesterol concentrations in serum according to the data of Galizia et al. Statistical processing of clinical examination and laboratory data was performed using the standard software package for personal computers "Microsoft Excel-2007" for Windows.Scientific novelty. It was established that according to the dichotomous values proposed by Galizia G. et al., the average serum albumin level at ill individuals with CRAS is 1 point, the concentration of total cholesterol in the blood is 0 points. Determination of NLR, LMR in CRAS showed that NLR was 1.88 times higher than the similar indicator of the control group, and the LMR indicator was 2.34 times lower than the indicator of patients in the control group. Calculation of the scores of inflammatory biomarkers NLR and LMR showed that both indices are estimated at 1 point. The final score of the NPS index was 3 points, which is high and associated with a potentially poor outcome. Conclusions. The results of our study indicate a relationship between CRAS and changes in the Neapoles Prognostic Scale using the nutritional prognostic index and systemic inflammation at ill individuals with CRAS. The innovative NPS scoring system we used, which is associated with the nutritional factor and inflammatory response at ill individuals with CRAS, may be useful for predicting the course of the disease.
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