DYNAMICS OF MEDIUM MOLECULAR WEIGHT PEPTIDES IN PATIENTS WITH GENERALAZED PERIODONTITIS ACCOMPAINED BY DIFFERENT REACTIVITY OF THE ORGANISM

Abstract

The role of the factor initiating the development of inflammatory-destructive process in periodontal tissues belongs to periodontopathogenic microorganisms. The complex of microcirculatory reactions to damage initiates tissue hypoxia, activation of free radical processes, disorganization of biomembranes with the release of biologically active substances, prostaglandins, cytokines, medium molecular weight peptides, etc. The aim of the study was to study the dynamics of medium molecular peptides in the blood of patients with generalized periodontitis accompanied by normo-, hyper- and hyporeactivity of the body after patch surgery. Materials and methods. 216 people aged between 45 and 55 years with the diagnosis of generalized periodontitis were examined. Depending on the condition of reactivity of the body, patients were divided into three groups: the first was made up by patients with normoreaction (132 people, 61%); the second group consisted of people with hyperreaction (46 people, 21%); the third included patients with hyporeaction (38 people, 18%). According to the indications, the patients with generalized periodontitis of II, III degrees of severity underwent patch surgery. Blood sampling was performed after the surgery on the 1st, 2nd, 4th, 6th and 9th day. The content of medium molecular weight peptides was determined by spectrophotometry. Research results and their discussion. The results of this study showed that the condition of patients with generalized periodontitis with normoreactivity of the body after the surgery was characterized by an initial increase followed by normalization of the mediators of endogenous intoxication. Hyperreactivity of the body in patients with generalized periodontitis was accompanied by a slow involution of all the the fractions of SMP in the blood with their imbalance until the end of observations. Hyporeactivity of the body in patients with generalized periodontitis was followed by the slow involution of all the fractions of SMP in the blood. Conclusions. Correction of altered parameters in patients with generalized periodontitis with impaired (hyper- and hypo-) reactivity of the body with bringing them to values which are typical for normoreactivity is considered to be a condition for optimizing the healing of mucosa and bone wound after surgery and further stabilization of the process in periodontal tissues.