THE STUDY OF THE DISORDERS IN METABOLISM OF INTERCELLULAR MATRIX OF ORAL AND PERIODONTAL MUCOUS MEMBRANE IN RATS AT SIMULATED PERIODONTITIS
Keywords:
simulation of periodontitis, collagenase, intercellular matrix, glycosamineglycanes, inflammation of oral mucous membrane, periodontal tissues, disorders in mineral metabolismAbstract
The aim of the investigation. The simulation of the experimental periodontitis in old rats and, in connection with this, the study of the disorders in metabolism of intercellular matrix of mucous membrane of oral cavity and periodontium. The materials and methods. At the experiments with 15 white she-rats of 18 months old periodontitis was simulat-ed with subgingival introduction of exogenous collagenase. The disorders in metabolism of intercellular matrix of oral cavity and osseous tissue of periodontium in old rats were expressed in the considerable degradation of gel, composing the basis of the intercellular matrix. The essential reduction of the contents of glycosamineglycanes and ions of magnesium in oral mucous membrane and the decrease of the concentration of ions of zinc – in periodontal bone speak of this phenomenon. Inflammation, the considerable acti-vation of the processes of lipids peroxide-oxidation and insufficient functioning of the enzymes of antioxidant effect in oral tissues took place in oral mucous membrane. The disorders in mineral metabolism were observed in periodontal osseous tissue under the influence of collagenase. So, as the result of simulation of periodontitis with subgingival introduction of collagenase the disorders in metab-olism of intercellular matrix of oral and periodontal mucous membrane in old rats were revealed.
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