METHYLING OF IL6 AND MMP13 GENE PROMOTORS IN PATIENTS WITH METABOLIC SYNDROME AND TYPE 2 DIABETES ON THE BACKGROUND OF CHRONIC PERIODONTITIS
DOI:
https://doi.org/10.35220/2523-420X/2020.1.13Keywords:
DNA methylation, IL6 and MMP13 genes, chronic generalized periodontitis, diabetes mellitus, metabolic syndromeAbstract
In the pathogenesis of periodontitis and its progression, important role belongs to bone resorption mechanisms, which must be taken into account during orthopedic treatment. Inflammatory cytokines and matrix metalloproteinases induce this mechanism. A DNA methylation study was conducted to evaluate the epigenomic variations in the promoters of the IL6 and MMP13 genes in patients with chronic periodontal disease on the background of metabolic syndrome and type 2 diabetes. A correlation analysis between the degree of methylated DNA of the IL6 and MMP13 genes, as well as the content of IL6 and MMP13 in the oral liquid of patients with chronic generalized periodontitis, showed a high positive relationship between these cytokines associated with the degree of chronic periodontitis. Hypomethylation of IL6 and MMP13 gene promoters in patients with chronic periodontitis on the background of metabolic syndrome and type 2 diabetes mellitus leads to an activation of these genes, increased synthesis of proinflammatory cytokine IL6 and metalloproteinase MMP13, which leads to tissue destruction in the focus of inflammation and aggravation of periodontitis.
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