EVALUATION OF THE EFFECTIVENESS OF A THERAPEUTIC-PROPHYLACTIC COMPLEX OF PREPARATIONS IN PATIENTS WITH SINGLE DEFECTS OF THE DENTAL ARCHES IN TERMS OF COMPLICATIONS AFTER DENTAL IMPLANTATION

Abstract

Post-operative complications remain one of the leading causes of reduced success rates of dental implantation in patients with single-tooth bounded edentulous spaces. Optimising pharmacological support by employing multicomponent therapeutic-prophylactic complexes that combine antioxidant, anti-inflammatory, immunomodulatory and osteotropic activities is therefore a topical issue in contemporary dentistry. The purpose of the study was to evaluate the efficacy of the proposed therapeutic drug complex on the frequency and severity of post-operative complications following dental implantation in patients with single-tooth bounded edentulous spaces. Materials and methods. Thirty-seven patients aged 18–22 years who underwent implantsupported prosthetic rehabilitation were examined. Two clinical cohorts were formed: the main group (n=20), which received a multicomponent therapeutic-prophylactic complex in addition to standard care, and a comparison group (n=17), which received standard care only. Complications were graded as mild, moderate, severe, or absent at 7 days, 2 weeks, 3 months and 6 months postsurgery. Statistical significance of intergroup differences was evaluated using Student’s t-test (p<0.01). Research results. In the comparison group, mild complications occurred in 17.6% and moderate complications in 11.7% of patients; no severe events were recorded. In the main group, mild complications were observed in 5% of cases, whereas moderate and severe complications were absent. The proportion of patients without complications reached 95% in the main group versus 70.7% in the control group (p<0.01). Conclusions. Administration of a therapeuticprophylactic complex that integrates antioxidant, antiinflammatory, immunomodulatory and osteotropic components significantly reduces the frequency and severity of post-operative complications after dental implantation and increases the proportion of uneventful healing to 95%.