CORRECTION OF BIOCHEMICAL PARAMETERS OF PERIODONTAL BONE TISSUE OF RATS DURING EXPERIMENTAL SIMULATION OF PERIODONTITIS ON THE BACKGROUND OF ORTHODONTIC TOOTH MOVEMENT
DOI:
https://doi.org/10.35220/2523-420X/2023.1.2Keywords:
experiment, rats, orthodontic intervention, biochemical parametersAbstract
Dental anomalies are among the main dental diseases and are characterized by a high prevalence. Thus, planning of therapeutic and preventive measures, development or improvement of existing methods of gingivitis therapy in adolescents is an integral part of effective treatment of dental anomalies in them with the help of fixed orthodontic structures. Therefore, conducting experimental studies of the developed medical and preventive complex is an urgent task of modern dentistry. Purpose of the study. Experimental assessment in rats, against the background of a model of peroxide periodontitis and orthodontic movement of teeth, changes in the biochemical parameters of periodontal bone tissue under the influence of developed therapeutic and preventive measures. Materials and methods of research. The following preparations "Spirulina extract" (Primaflora, Ukraine) and "Calciker" (Indoko Remedis Limited, India) were used in the experimental work. A mucozoadhesive gel for the oral cavity was prepared on the basis of spirulina. Experiments were conducted on 25 white Wistar rats (males, 5 months, weight 325±18 g), which were divided into 4 groups. Results and discussion. In the bone tissue of the periodontium of rats with simulated pathology, the processes of mineralization are disturbed with the predominance of the activity of destructive enzymes, a decrease in protein and calcium was observed. Prophylactic use of the proposed drugs on the background of simulated peroxide periodontitis with additional orthodontic tooth movement had a corrective effect on changes in bone tissue. The most effective results were observed after the use of complex prevention. In the bone tissue of the jaws of rats, the complex showed the properties of reducing the destructive processes of both the mineral and organic part of the periodontal bone tissue of rats, and also stimulated the processes of its mineralization in periodontogenic conditions and orthodontic intervention.
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