RATS BLOOD SERUM BIOCHEMICAL PARAMETERS ON MODELING OF METABOLIC SYNDROME AND ORTHODONTIC MOVEMENT OF TEETH
DOI:
https://doi.org/10.35220/2523-420X/2019.1.1Keywords:
rats, blood serum, metabolic syndrome, orthodontic teeth movement, therapeutic and prophylactic complexAbstract
Modeling of metabolic syndrome and orthodontic movement of teeth rats in the experiment led to the development of hyperglycemia, reduction of nonspecific antimicrobial and antioxidant protection of the body and, consequently, an increase in microbial contamination, intensification of systemic lipid peroxidation. The fixation of orthodontic springs in rats oral cavity led to a further decrease in non-specific resistance and a simultaneous increase in the intensity of systemic inflammation. Treatment and preventive measures prevented an increase in the level of glucose, malonic dialdehyde, elastase and urease activity, dysbiosis, as well as maintaining high levels of non-specific protection – cata-lase activity, antioxidant-prooxidant index and lysozyme activity.
References
Grundy SM. Metabolic syndrome pandemic / SM Grundy //Arterioscler Thromb Vasc Biol. – 2008. – № 28(4). – Р. 629-636.
Ogden CL., Carroll MD., Curtin LR. et al. Preva-lence of high body mass index in US children and adolescents, 2007–2008. / CL Ogden, MD Carroll, LR Curtin, MM Lamb, KM Flegal // Journal of the American Medical Association. – 2010. – 303. – Р. 242–249.
Леонтьева И.В. Метаболический синдром как пе-диатрическая проблема / И.В. Леонтьева // Российский вестник перинатологии и педиатрии. – 2008. – Т.53.– № 3. – С. 4-16.
Толстикова Н. Метаболический синдром у детей и подростков // З турботою про дитину. – 2015. – № 4(54).
Zimmet P. On behalf of International Diabetes Feder-ation Task Force on Epidemiology and Prevention of Diabetes. The metabolic syndrome in children and adolescents -how should it be defined? / P Zimmet, KGMM Alberti, F Kaufman et al. // Lancet. – 2007. – Vol.369. – P. 2059-2061.
Проданчук А.И. Развитие заболеваний пародонта у детей с сахарным диабетом // Молодой ученый. – 2015. – № 11. – С. 708- 710.
Mona Aly Abbassy, Ippei Watari,Ahmed Samir Bakry et al. The Effect of Type 1 Diabetes Mellitus on the Dento Craniofacial Complex / Mona Aly Abbassy, Ippei Watari, Ahmed Samir Bakry, Takashi Ono // Type 1 Diabetes: A Guide for Children, Adolescents, Young Adults and Their Caregivers, Third Edition. – 2005. – June 7. – Р. 401-430.
Bensch L, Braem M, Van Acker K et al. Orthodon-tic treatment considerations in patients with diabetes mellitus / L Bensch, M Braem, K Van Acker, G Willems // American Jour-nal of Orthodontics and Dentofacial Orthopedics. – 2003. – № 123(1). – С. 74-78.
Патент 21033 Україна МПК G09B 23/28 Спосіб моделювання ортодонтичного переміщення зубів щурів / Горохівський В.Н. Мірчук Б.М., Дєньга О.В.; опубл.15.02.2007, Бюл. №2.
