EXPERIMENTAL EVALUATION OF BIOCHEMICAL MARKERS OF INFLAMMATION IN RAT GINGIVAL HOMOGENATES IN THE CONTEXT OF IMPLANT FIXATION AND THERAPEUTICPROPHYLACTIC MEASURES

Abstract

The purpose of this study. Evaluation of the effect of a therapeutic complex of drugs on markers of inflammation in rat gum homogenates after implant fixation. Material and research methods. Experimental studies were conducted, during which 45 male rats of 7 months of age were used, with an average weight of 340-370 G. the implant was fixed to Animals of the experimental groups under thiopental anesthesia. Markers of inflammation – elastase and acid phosphatase activity-were determined in gum homogenates. After fixing the implant the next day, the experimental animals were orally administered a complex of drugs in the form of suspensions, which had antiinflammatory, antioxidant and anti-dysbiotic properties, and the control group was injected with water in the same volume. The animals were divided into 3 groups: intact; control with implant fixation + water; implant fixation + a complex of drugs. The duration of the experiment was 30 days. Rats were removed from the experiment by euthanasia under thiopental anesthesia (40 mg/kg) after 30 days by bloodletting from the heart. The use of a therapeutic complex of drugs leads to a significant decrease in the activity of inflammatory markers: after prolonged oral administration of complex drugs, the activity of acid phosphatase decreased by 2.5 times, and elastase – by 1.4 times. This indicates a pronounced anti-inflammatory effect of the treatment complex. The introduction of this treatment complex into clinical practice can help improve the results of implantation treatment by reducing inflammatory complications and increasing the longterm stability of implants. Conclusions. The introduction of this treatment complex into clinical practice can help improve the results of implantation treatment by reducing inflammatory complications and increasing the long-term stability of implants.