ASSESSMENT OF THE EFFECT OF A THERAPEUTIC DRUG COMPLEX ON SERUM BIOMARKERS IN EXPERIMENTAL ANIMALS FOLLOWING DENTAL IMPLANT PLACEMENT

Abstract

Surgical insertion of dental implants is accompanied by local inflammation and oxidative stress, which can hinder subsequent osseointegration. Correction of these alterations using combined anti-inflammatory and antioxidant agents is a current challenge in modern implantology. The purpose of the study was to evaluate the effect of a newly developed therapeutic-prophylactic complex (TPC) on serum biochemical markers in experimental rats after dental implant placement. Materials and methods. Thirty outbred male white rats (4 months old, 220–250 g) were divided into three groups (n = 10): intact; control (implantation + drinking water per os); experimental (implantation + TPC per os for 30 days). Sixty days postsurgery, serum elastase activity, malondialdehyde (MDA) concentration, catalase activity, and the antioxidant– pro-oxidant index (API) were determined. Statistical analysis employed Student’s t-test (p < 0.01). Research results. In control animals, implantation increased elastase activity by 28.0% and MDA by 61.9%, while catalase activity decreased by 56.3% and API fell 2.5- fold compared with the intact group. TPC administration reduced elastase by 14.7% (p < 0.05) and MDA by 27.9% (p < 0.02) versus control, simultaneously restoring catalase activity (+43.7%; p < 0.002) and doubling API (p < 0.001), bringing these parameters close to intact values. Conclusions. The developed therapeutic-prophylactic complex exhibits pronounced anti-inflammatory and antioxidant effects in the context of dental implantation: it normalises elastase activity, decreases lipid peroxidation intensity, and restores antioxidant system function. These findings confirm the promise of the TPC for preventing oxidative-inflammatory complications and enhancing implant osseointegration success.