THE INFLUENCE OF EPITHELIOTROPIC GENOTOXIC AGENT UPON THE STATE OF PERIODONTIUM AND ORAL MUCOUS MEMBRANE IN RATS

Authors

  • S. A. Snaider

Keywords:

toxic agent, lipids peroxide oxidation, inflammation, absorption of osseous tissue, cytomorphologic studies of cheek mucous membrane

Abstract

At the experiments with 15 white he-rats of 1 month old the mechanisms of system and local influence of toxic agent DDE (2.2-Bis (7-chicrophenic)-2 dichloroethylene) upon the state of oral tissues were studied. Oral introduction of DDE within relatively short terms of the experiment (35 days) has caused inflammatory phenomena in blood serum and liver of animals (system). Under the influence of toxic agent the pathologic changes in oral tissues (local) – the phenomena of inflammation in gum; the partial inactivation of some preventive regulatory albumens; the intensification of absorptive processes and the disorders in mineral metabolism in osseous structures of periodontium were observed. The confirmation of the toxic influence of DDE upon oral mucous membrane is the result of cytomorphologic studies: the display of vacuolar dystrophy in epithelium; the structural changes in conjunctive tissue of the proper mucous plate (edema, thickening of collagenic fibers) and its cellular contents (the appearance of migrated leucocytes from blood vessel). One of the most pathogenic influences DDE had upon genetic apparatus of epithelial cells – mitotic index lowered considerably and, at the same time, the number of pathologic mitoses grew; skewness of fission was noticed in chromosomes.

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Published

2021-12-15

How to Cite

Шнайдер, С. А. (2021). THE INFLUENCE OF EPITHELIOTROPIC GENOTOXIC AGENT UPON THE STATE OF PERIODONTIUM AND ORAL MUCOUS MEMBRANE IN RATS. Innovation in Stomatology, (2), 11–14. Retrieved from http://innovacii.od.ua/index.php/mainjournal/article/view/47

Issue

Section

EXPERIMENTAL AND THEORETICAL SECTION

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